Publications

Solís-Ruiz, J. A., Barthe, A., Riegel, G., Saavedra-Díaz, R. O., Gaiddon, C., & Le Lagadec, R. (2020). Light activation of cyclometalated ruthenium complexes drives towards caspase 3 dependent apoptosis in gastric cancer cells. Journal of Inorganic Biochemistry, 208, 111080. https://doi.org/10.1016/j.jinorgbio.2020.111080
Licona, C., Delhorme, J.-B., Riegel, G., Vidimar, V., Cerón-Camacho, R., Boff, B., Venkatasamy, A., Tomasetto, C., da Silva Figueiredo Celestino Gomes, P., Rognan, D., Freund, J.-N., Le Lagadec, R., Pfeffer, M., Gross, I., Mellitzer, G., & Gaiddon, C. (2020). Anticancer activity of ruthenium and osmium cyclometalated compounds: identification of ABCB1 and EGFR as resistance mechanisms. Inorganic Chemistry Frontiers, 7(3), 678–688. https://doi.org/10.1039/C9QI01148J
Miller, J. J., Blanchet, A., Orvain, C., Nouchikian, L., Reviriot, Y., Clarke, R. M., Martelino, D., Wilson, D., Gaiddon, C., & Storr, T. (2019). Bifunctional ligand design for modulating mutant p53 aggregation in cancer. Chemical Science, 10(46), 10802–10814. https://doi.org/10.1039/c9sc04151f
Spaety, M.-E., Gries, A., Badie, A., Venkatasamy, A., Romain, B., Orvain, C., Yanagihara, K., Okamoto, K., Jung, A. C., Mellitzer, G., Pfeffer, S., & Gaiddon, C. (2019). HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway. Cancers, 11(11), 1747. https://doi.org/10.3390/cancers11111747
Coliat, P., Ramolu, L., Jégu, J., Gaiddon, C., Jung, A. C., & Pencreach, E. (2019). Constitutive or Induced HIF-2 Addiction is Involved in Resistance to Anti-EGFR Treatment and Radiation Therapy in HNSCC. Cancers, 11(10). https://doi.org/10.3390/cancers11101607
Liang, Y., Hou, L., Li, L., Li, L., Zhu, L., Wang, Y., Huang, X., Hou, Y., Zhu, D., Zou, H., Gu, Y., Weng, X., Wang, Y., Li, Y., Wu, T., Yao, M., Gross, I., Gaiddon, C., Luo, M., … Meng, X. (2019). Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway. Oncogene. https://doi.org/10.1038/s41388-019-1035-8
Job, S., Reyniès, A. de, Heller, B., Weiss, A., Guérin, E., Macabre, C., Ledrappier, S., Bour, C., Wasylyk, C., Etienne-Selloum, N., Brino, L., Gaiddon, C., Wasylyk, B., & Jung, A. C. (2019). Preferential Response of Basal-Like Head and Neck Squamous Cell Carcinoma Cell Lines to EGFR-Targeted Therapy Depending on EREG-Driven Oncogenic Addiction. Cancers, 11(6). https://doi.org/10.3390/cancers11060795
Santoro, A., Vileno, B., Palacios, Ò., Peris-Díaz, M. D., Riegel, G., Gaiddon, C., Krężel, A., & Faller, P. (2019). Reactivity of Cu(ii)-, Zn(ii)- and Fe(ii)-thiosemicarbazone complexes with glutathione and metallothionein: from stability to dissociation to transmetallation. Metallomics: Integrated Biometal Science, 11(5), 994–1004. https://doi.org/10.1039/c9mt00061e
Vidimar, V., Licona, C., Cerón-Camacho, R., Guerin, E., Coliat, P., Venkatasamy, A., Ali, M., Guenot, D., Le Lagadec, R., Jung, A. C., Freund, J.-N., Pfeffer, M., Mellitzer, G., Sava, G., & Gaiddon, C. (2019). A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53. Cancer Letters, 440–441, 145–155. https://doi.org/10.1016/j.canlet.2018.09.029
Borel, C., Regnier-Gavier, O., Carinato, H., Guihard, S., Antoni, D., Demarchi, M., Sirlin, F., Exinger, D., Petit-Jean, E., Thiery, A., Bronner, G., Schultz, P., Flesch, H., Frasie, V., Prébay, D., Petit, T., Jung, A. C., Burgy, M., & Coliat, P. (2018). Interest to consider re-challenging by cetuximab and platinum containing regimen in recurrent Head and Neck Cancer. Oncotarget, 9(101), 37581–37588. https://doi.org/10.18632/oncotarget.26506
Miller, J. J., Orvain, C., Jozi, S., Clarke, R. M., Smith, J. R., Blanchet, A., Gaiddon, C., Warren, J. J., & Storr, T. (2018). Multifunctional Compounds for Activation of the p53-Y220C Mutant in Cancer. Chemistry (Weinheim an Der Bergstrasse, Germany), 24(67), 17734–17742. https://doi.org/10.1002/chem.201802677
Lam, N. Y. S., Truong, D., Burmeister, H., Babak, M. V., Holtkamp, H. U., Movassaghi, S., Ayine-Tora, D. M., Zafar, A., Kubanik, M., Oehninger, L., Söhnel, T., Reynisson, J., Jamieson, S. M. F., Gaiddon, C., Ott, I., & Hartinger, C. G. (2018). From Catalysis to Cancer: Toward Structure-Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents. Inorganic Chemistry, 57(22), 14427–14434. https://doi.org/10.1021/acs.inorgchem.8b02634
Minault, Q., Gaiddon, C., Veillon, F., & Venkatasamy, A. (2018). The Champagne sign. Abdominal Radiology (New York), 43(10), 2888–2889. https://doi.org/10.1007/s00261-018-1544-x
Chow, M. J., Babak, M. V., Tan, K. W., Cheong, M. C., Pastorin, G., Gaiddon, C., & Ang, W. H. (2018). Induction of the Endoplasmic Reticulum Stress Pathway by Highly Cytotoxic Organoruthenium Schiff-Base Complexes. Molecular Pharmaceutics, 15(8), 3020–3031. https://doi.org/10.1021/acs.molpharmaceut.8b00003
Gass, B., Marrer, E., Bara, S., Ligier, K., Molinié, F., Colonna, M., Daubisse-Marliac, L., Trétarre, B., Lapôtre-Ledoux, B., Woronoff, A.-S., Guizard, A.-V., Bouvier, V., Troussard, X., Gaiddon, C., Klein, D., Velten, M., & Jégu, J. (2018). Use of a case-mix approach to study the trends in the incidence of second primary cancers. Annals of Epidemiology, 28(5), 322–327. https://doi.org/10.1016/j.annepidem.2018.02.008
Babak, M. V., Pfaffeneder-Kmen, M., Meier-Menches, S. M., Legina, M. S., Theiner, S., Licona, C., Orvain, C., Hejl, M., Hanif, M., Jakupec, M. A., Keppler, B. K., Gaiddon, C., & Hartinger, C. G. (2018). Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action. Inorganic Chemistry, 57(5), 2851–2864. https://doi.org/10.1021/acs.inorgchem.7b03210
Makarchuk, S., Beyer, N., Gaiddon, C., Grange, W., & Hébraud, P. (2018). Holographic Traction Force Microscopy. Scientific Reports, 8(1), 3038. https://doi.org/10.1038/s41598-018-21206-2
Manfredelli, S., Delhorme, J.-B., Venkatasamy, A., Gaiddon, C., Brigand, C., Rohr, S., & Romain, B. (2017). Could a Feeding Jejunostomy be Integrated into a Standardized Preoperative Management of Oeso-gastric Junction Adenocarcinoma? Annals of Surgical Oncology, 24(11), 3324–3330. https://doi.org/10.1245/s10434-017-5945-9
Chow, M. J., Alfiean, M., Pastorin, G., Gaiddon, C., & Ang, W. H. (2017). Apoptosis-independent organoruthenium anticancer complexes that overcome multidrug resistance: self-assembly and phenotypic screening strategies. Chemical Science, 8(5), 3641–3649. https://doi.org/10.1039/c7sc00497d
Estrada‐Montaño, A. S., Ryabov, A. D., Gries, A., Gaiddon, C., & Lagadec, R. L. (2017). Iron(III) Pincer Complexes as a Strategy for Anticancer Studies. European Journal of Inorganic Chemistry, 2017(12), 1673–1678. https://doi.org/10.1002/ejic.201601350
Licona, C., Spaety, M.-E., Capuozzo, A., Ali, M., Santamaria, R., Armant, O., Delalande, F., Van Dorsselaer, A., Cianferani, S., Spencer, J., Pfeffer, M., Mellitzer, G., & Gaiddon, C. (2017). A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin. Oncotarget, 8(2), 2568–2584. https://doi.org/10.18632/oncotarget.13711
Mirghani, H., Jung, A. C., & Fakhry, C. (2017). Primary, secondary and tertiary prevention of human papillomavirus-driven head and neck cancers. European Journal of Cancer (Oxford, England: 1990), 78, 105–115. https://doi.org/10.1016/j.ejca.2017.03.021
Platet, N., Hinkel, I., Richert, L., Murdamoothoo, D., Moufok-Sadoun, A., Vanier, M., Lavalle, P., Gaiddon, C., Vautier, D., Freund, J.-N., & Gross, I. (2017). The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton. Cancer Letters, 386, 57–64. https://doi.org/10.1016/j.canlet.2016.10.040
Khalil, G., Orvain, C., Fang, L., Barloy, L., Chaumont, A., Gaiddon, C., Henry, M., Kyritsakas, N., & Mobian, P. (2016). Monomeric Ti(iv)-based complexes incorporating luminescent nitrogen ligands: synthesis, structural characterization, emission spectroscopy and cytotoxic activities. Dalton Transactions (Cambridge, England: 2003), 45(47), 19072–19085. https://doi.org/10.1039/c6dt03477b
Bonnin, N., Armandy, E., Carras, J., Ferrandon, S., Battiston-Montagne, P., Aubry, M., Guihard, S., Meyronet, D., Foy, J.-P., Saintigny, P., Ledrappier, S., Jung, A. C., Rimokh, R., Rodriguez-Lafrasse, C., & Poncet, D. (2016). MiR-422a promotes loco-regional recurrence by targeting NT5E/CD73 in head and neck squamous cell carcinoma. Oncotarget, 7(28), 44023–44038. https://doi.org/10.18632/oncotarget.9829
Chow, M. J., Babak, M. V., Wong, D. Y. Q., Pastorin, G., Gaiddon, C., & Ang, W. H. (2016). Structural Determinants of p53-Independence in Anticancer Ruthenium-Arene Schiff-Base Complexes. Molecular Pharmaceutics, 13(7), 2543–2554. https://doi.org/10.1021/acs.molpharmaceut.6b00348
Chow, M. J., Licona, C., Pastorin, G., Mellitzer, G., Ang, W. H., & Gaiddon, C. (2016). Structural tuning of organoruthenium compounds allows oxidative switch to control ER stress pathways and bypass multidrug resistance. Chemical Science, 7(7), 4117–4124. https://doi.org/10.1039/c6sc00268d
von Grabowiecki, Y., Abreu, P., Blanchard, O., Palamiuc, L., Benosman, S., Mériaux, S., Devignot, V., Gross, I., Mellitzer, G., Gonzalez de Aguilar, J. L., & Gaiddon, C. (2016). Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63. ELife, 5, e10528. https://doi.org/10.7554/eLife.10528
Rico Bautista, H., Saavedra Díaz, R. O., Shen, L. Q., Orvain, C., Gaiddon, C., Le Lagadec, R., & Ryabov, A. D. (2016). Impact of cyclometalated ruthenium(II) complexes on lactate dehydrogenase activity and cytotoxicity in gastric and colon cancer cells. Journal of Inorganic Biochemistry, 163, 28–38. https://doi.org/10.1016/j.jinorgbio.2016.07.014
Jung, A. C., Ray, A.-M., Ramolu, L., Macabre, C., Simon, F., Noulet, F., Blandin, A.-F., Renner, G., Lehmann, M., Choulier, L., Kessler, H., Abecassis, J., Dontenwill, M., & Martin, S. (2015). Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties. Oncotarget, 6(39), 41884–41901. https://doi.org/10.18632/oncotarget.6099
Hanns, E., Job, S., Coliat, P., Wasylyk, C., Ramolu, L., Pencreach, E., Suarez-Carmona, M., Herfs, M., Ledrappier, S., Macabre, C., Abecassis, J., Wasylyk, B., & Jung, A. C. (2015). Human Papillomavirus-related tumours of the oropharynx display a lower tumour hypoxia signature. Oral Oncology, 51(9), 848–856. https://doi.org/10.1016/j.oraloncology.2015.06.003
Chamard-Jovenin, C., Jung, A. C., Chesnel, A., Abecassis, J., Flament, S., Ledrappier, S., Macabre, C., Boukhobza, T., & Dumond, H. (2015). From ERα66 to ERα36: a generic method for validating a prognosis marker of breast tumor progression. BMC Systems Biology, 9, 28. https://doi.org/10.1186/s12918-015-0178-7
Tasan, S., Licona, C., Doulain, P.-E., Michelin, C., Gros, C. P., Le Gendre, P., Harvey, P. D., Paul, C., Gaiddon, C., & Bodio, E. (2015). Gold-phosphine-porphyrin as potential metal-based theranostics. Journal of Biological Inorganic Chemistry: JBIC: A Publication of the Society of Biological Inorganic Chemistry, 20(1), 143–154. https://doi.org/10.1007/s00775-014-1220-8
von Grabowiecki, Y., Licona, C., Palamiuc, L., Abreu, P., Vidimar, V., Coowar, D., Mellitzer, G., & Gaiddon, C. (2015). Regulation of a Notch3-Hes1 pathway and protective effect by a tocopherol-omega alkanol chain derivative in muscle atrophy. The Journal of Pharmacology and Experimental Therapeutics, 352(1), 23–32. https://doi.org/10.1124/jpet.114.216879
Chow, M. J., Licona, C., Yuan Qiang Wong, D., Pastorin, G., Gaiddon, C., & Ang, W. H. (2014). Discovery and investigation of anticancer ruthenium-arene Schiff-base complexes via water-promoted combinatorial three-component assembly. Journal of Medicinal Chemistry, 57(14), 6043–6059. https://doi.org/10.1021/jm500455p
Klajner, M., Licona, C., Fetzer, L., Hebraud, P., Mellitzer, G., Pfeffer, M., Harlepp, S., & Gaiddon, C. (2014). Subcellular localization and transport kinetics of ruthenium organometallic anticancer compounds in living cells: a dose-dependent role for amino acid and iron transporters. Inorganic Chemistry, 53(10), 5150–5158. https://doi.org/10.1021/ic500250e
Robertson, E. D., Wasylyk, C., Ye, T., Jung, A. C., & Wasylyk, B. (2014). The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PloS One, 9(11), e113050. https://doi.org/10.1371/journal.pone.0113050
Wasylyk, B., Abecassis, J., & Jung, A. C. (2013). Identification of clinically relevant HPV-related HNSCC: in p16 should we trust? Oral Oncology, 49(10), e33-37. https://doi.org/10.1016/j.oraloncology.2013.07.014
Anthwal, N., Pelling, M., Claxton, S., Mellitzer, G., Collin, C., Kessaris, N., Richardson, W. D., Gradwohl, G., & Ang, S.-L. (2013). Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity. Disease Models & Mechanisms, 6(5), 1133–1145. https://doi.org/10.1242/dmm.011916
Ennen, M., Klotz, R., Touche, N., Pinel, S., Barbieux, C., Besancenot, V., Brunner, E., Thiebaut, D., Jung, A. C., Ledrappier, S., Domenjoud, L., Abecassis, J., Plénat, F., Grandemange, S., & Becuwe, P. (2013). DDB2: a novel regulator of NF-κB and breast tumor invasion. Cancer Research, 73(16), 5040–5052. https://doi.org/10.1158/0008-5472.CAN-12-3655
Jung, A. C., Job, S., Ledrappier, S., Macabre, C., Abecassis, J., de Reyniès, A., & Wasylyk, B. (2013). A poor prognosis subtype of HNSCC is consistently observed across methylome, transcriptome, and miRNome analysis. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 19(15), 4174–4184. https://doi.org/10.1158/1078-0432.CCR-12-3690
Jung, A. C. (2013). Can liberating p53 from E6 free patients from HPV-related head and neck tumors? Cell Cycle (Georgetown, Tex.), 12(6), 868. https://doi.org/10.4161/cc.24101
Boff, B., Gaiddon, C., & Pfeffer, M. (2013). Cancer cell cytotoxicity of cyclometalated compounds obtained with osmium(II) complexes. Inorganic Chemistry, 52(5), 2705–2715. https://doi.org/10.1021/ic302779q
Jung, A. C., Guihard, S., Krugell, S., Ledrappier, S., Brochot, A., Dalstein, V., Job, S., de Reynies, A., Noël, G., Wasylyk, B., Clavel, C., & Abecassis, J. (2013). CD8-alpha T-cell infiltration in human papillomavirus-related oropharyngeal carcinoma correlates with improved patient prognosis. International Journal of Cancer, 132(2), E26-36. https://doi.org/10.1002/ijc.27776
Vidimar, V., Meng, X., Klajner, M., Licona, C., Fetzer, L., Harlepp, S., Hébraud, P., Sidhoum, M., Sirlin, C., Loeffler, J.-P., Mellitzer, G., Sava, G., Pfeffer, M., & Gaiddon, C. (2012). Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity. Biochemical Pharmacology, 84(11), 1428–1436. https://doi.org/10.1016/j.bcp.2012.08.022
Ribeiro, N., Thuaud, F., Bernard, Y., Gaiddon, C., Cresteil, T., Hild, A., Hirsch, E. C., Michel, P. P., Nebigil, C. G., & Désaubry, L. (2012). Flavaglines as potent anticancer and cytoprotective agents. Journal of Medicinal Chemistry, 55(22), 10064–10073. https://doi.org/10.1021/jm301201z
Guihard, S., Ramolu, L., Macabre, C., Wasylyk, B., Noël, G., Abecassis, J., & Jung, A. C. (2012). The NEDD8 conjugation pathway regulates p53 transcriptional activity and head and neck cancer cell sensitivity to ionizing radiation. International Journal of Oncology, 41(4), 1531–1540. https://doi.org/10.3892/ijo.2012.1584
Guihard, S., Jung, A. C., & Noël, G. (2012). [High-risk human papilloma virus associated oropharynx squamous cell carcinomas: clinical, biological implications and therapeutical perspectives]. Cancer Radiotherapie: Journal De La Societe Francaise De Radiotherapie Oncologique, 16(1), 34–43. https://doi.org/10.1016/j.canrad.2011.11.001
Bergamo, A., Gaiddon, C., Schellens, J. H. M., Beijnen, J. H., & Sava, G. (2012). Approaching tumour therapy beyond platinum drugs: status of the art and perspectives of ruthenium drug candidates. Journal of Inorganic Biochemistry, 106(1), 90–99. https://doi.org/10.1016/j.jinorgbio.2011.09.030
Benosman, S., Meng, X., Von Grabowiecki, Y., Palamiuc, L., Hritcu, L., Gross, I., Mellitzer, G., Taya, Y., Loeffler, J.-P., & Gaiddon, C. (2011). Complex regulation of p73 isoforms after alteration of amyloid precursor polypeptide (APP) function and DNA damage in neurons. The Journal of Biological Chemistry, 286(50), 43013–43025. https://doi.org/10.1074/jbc.M111.261271
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