Publications

Solís-Ruiz, J. A., Barthe, A., Riegel, G., Saavedra-Díaz, R. O., Gaiddon, C., & Le Lagadec, R. (2020). Light activation of cyclometalated ruthenium complexes drives towards caspase 3 dependent apoptosis in gastric cancer cells. Journal of Inorganic Biochemistry, 208, 111080. https://doi.org/10.1016/j.jinorgbio.2020.111080
Licona, C., Delhorme, J.-B., Riegel, G., Vidimar, V., Cerón-Camacho, R., Boff, B., … Gaiddon, C. (2020). Anticancer activity of ruthenium and osmium cyclometalated compounds: identification of ABCB1 and EGFR as resistance mechanisms. Inorganic Chemistry Frontiers, 7(3), 678–688. https://doi.org/10.1039/C9QI01148J
Miller, J. J., Blanchet, A., Orvain, C., Nouchikian, L., Reviriot, Y., Clarke, R. M., … Storr, T. (2019). Bifunctional ligand design for modulating mutant p53 aggregation in cancer. Chemical Science, 10(46), 10802–10814. https://doi.org/10.1039/c9sc04151f
Spaety, M.-E., Gries, A., Badie, A., Venkatasamy, A., Romain, B., Orvain, C., … Gaiddon, C. (2019). HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway. Cancers, 11(11), 1747. https://doi.org/10.3390/cancers11111747
Coliat, P., Ramolu, L., Jégu, J., Gaiddon, C., Jung, A. C., & Pencreach, E. (2019). Constitutive or Induced HIF-2 Addiction is Involved in Resistance to Anti-EGFR Treatment and Radiation Therapy in HNSCC. Cancers, 11(10). https://doi.org/10.3390/cancers11101607
Liang, Y., Hou, L., Li, L., Li, L., Zhu, L., Wang, Y., … Meng, X. (2019). Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway. Oncogene. https://doi.org/10.1038/s41388-019-1035-8
Job, S., Reyniès, A. de, Heller, B., Weiss, A., Guérin, E., Macabre, C., … Jung, A. C. (2019). Preferential Response of Basal-Like Head and Neck Squamous Cell Carcinoma Cell Lines to EGFR-Targeted Therapy Depending on EREG-Driven Oncogenic Addiction. Cancers, 11(6). https://doi.org/10.3390/cancers11060795
Santoro, A., Vileno, B., Palacios, Ò., Peris-Díaz, M. D., Riegel, G., Gaiddon, C., … Faller, P. (2019). Reactivity of Cu(ii)-, Zn(ii)- and Fe(ii)-thiosemicarbazone complexes with glutathione and metallothionein: from stability to dissociation to transmetallation. Metallomics: Integrated Biometal Science, 11(5), 994–1004. https://doi.org/10.1039/c9mt00061e
Vidimar, V., Licona, C., Cerón-Camacho, R., Guerin, E., Coliat, P., Venkatasamy, A., … Gaiddon, C. (2019). A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53. Cancer Letters, 440441, 145–155. https://doi.org/10.1016/j.canlet.2018.09.029
Borel, C., Regnier-Gavier, O., Carinato, H., Guihard, S., Antoni, D., Demarchi, M., … Coliat, P. (2018). Interest to consider re-challenging by cetuximab and platinum containing regimen in recurrent Head and Neck Cancer. Oncotarget, 9(101), 37581–37588. https://doi.org/10.18632/oncotarget.26506
Miller, J. J., Orvain, C., Jozi, S., Clarke, R. M., Smith, J. R., Blanchet, A., … Storr, T. (2018). Multifunctional Compounds for Activation of the p53-Y220C Mutant in Cancer. Chemistry (Weinheim an Der Bergstrasse, Germany), 24(67), 17734–17742. https://doi.org/10.1002/chem.201802677
Lam, N. Y. S., Truong, D., Burmeister, H., Babak, M. V., Holtkamp, H. U., Movassaghi, S., … Hartinger, C. G. (2018). From Catalysis to Cancer: Toward Structure-Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents. Inorganic Chemistry, 57(22), 14427–14434. https://doi.org/10.1021/acs.inorgchem.8b02634
Minault, Q., Gaiddon, C., Veillon, F., & Venkatasamy, A. (2018). The Champagne sign. Abdominal Radiology (New York), 43(10), 2888–2889. https://doi.org/10.1007/s00261-018-1544-x
Chow, M. J., Babak, M. V., Tan, K. W., Cheong, M. C., Pastorin, G., Gaiddon, C., & Ang, W. H. (2018). Induction of the Endoplasmic Reticulum Stress Pathway by Highly Cytotoxic Organoruthenium Schiff-Base Complexes. Molecular Pharmaceutics, 15(8), 3020–3031. https://doi.org/10.1021/acs.molpharmaceut.8b00003
Gass, B., Marrer, E., Bara, S., Ligier, K., Molinié, F., Colonna, M., … Jégu, J. (2018). Use of a case-mix approach to study the trends in the incidence of second primary cancers. Annals of Epidemiology, 28(5), 322–327. https://doi.org/10.1016/j.annepidem.2018.02.008
Babak, M. V., Pfaffeneder-Kmen, M., Meier-Menches, S. M., Legina, M. S., Theiner, S., Licona, C., … Hartinger, C. G. (2018). Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action. Inorganic Chemistry, 57(5), 2851–2864. https://doi.org/10.1021/acs.inorgchem.7b03210
Makarchuk, S., Beyer, N., Gaiddon, C., Grange, W., & Hébraud, P. (2018). Holographic Traction Force Microscopy. Scientific Reports, 8(1), 3038. https://doi.org/10.1038/s41598-018-21206-2
Manfredelli, S., Delhorme, J.-B., Venkatasamy, A., Gaiddon, C., Brigand, C., Rohr, S., & Romain, B. (2017). Could a Feeding Jejunostomy be Integrated into a Standardized Preoperative Management of Oeso-gastric Junction Adenocarcinoma? Annals of Surgical Oncology, 24(11), 3324–3330. https://doi.org/10.1245/s10434-017-5945-9
Chow, M. J., Alfiean, M., Pastorin, G., Gaiddon, C., & Ang, W. H. (2017). Apoptosis-independent organoruthenium anticancer complexes that overcome multidrug resistance: self-assembly and phenotypic screening strategies. Chemical Science, 8(5), 3641–3649. https://doi.org/10.1039/c7sc00497d
Estrada‐Montaño, A. S., Ryabov, A. D., Gries, A., Gaiddon, C., & Lagadec, R. L. (2017). Iron(III) Pincer Complexes as a Strategy for Anticancer Studies. European Journal of Inorganic Chemistry, 2017(12), 1673–1678. https://doi.org/10.1002/ejic.201601350
Licona, C., Spaety, M.-E., Capuozzo, A., Ali, M., Santamaria, R., Armant, O., … Gaiddon, C. (2017). A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin. Oncotarget, 8(2), 2568–2584. https://doi.org/10.18632/oncotarget.13711
Mirghani, H., Jung, A. C., & Fakhry, C. (2017). Primary, secondary and tertiary prevention of human papillomavirus-driven head and neck cancers. European Journal of Cancer (Oxford, England: 1990), 78, 105–115. https://doi.org/10.1016/j.ejca.2017.03.021
Platet, N., Hinkel, I., Richert, L., Murdamoothoo, D., Moufok-Sadoun, A., Vanier, M., … Gross, I. (2017). The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton. Cancer Letters, 386, 57–64. https://doi.org/10.1016/j.canlet.2016.10.040
Khalil, G., Orvain, C., Fang, L., Barloy, L., Chaumont, A., Gaiddon, C., … Mobian, P. (2016). Monomeric Ti(iv)-based complexes incorporating luminescent nitrogen ligands: synthesis, structural characterization, emission spectroscopy and cytotoxic activities. Dalton Transactions (Cambridge, England: 2003), 45(47), 19072–19085. https://doi.org/10.1039/c6dt03477b
Bonnin, N., Armandy, E., Carras, J., Ferrandon, S., Battiston-Montagne, P., Aubry, M., … Poncet, D. (2016). MiR-422a promotes loco-regional recurrence by targeting NT5E/CD73 in head and neck squamous cell carcinoma. Oncotarget, 7(28), 44023–44038. https://doi.org/10.18632/oncotarget.9829
Chow, M. J., Babak, M. V., Wong, D. Y. Q., Pastorin, G., Gaiddon, C., & Ang, W. H. (2016). Structural Determinants of p53-Independence in Anticancer Ruthenium-Arene Schiff-Base Complexes. Molecular Pharmaceutics, 13(7), 2543–2554. https://doi.org/10.1021/acs.molpharmaceut.6b00348
Chow, M. J., Licona, C., Pastorin, G., Mellitzer, G., Ang, W. H., & Gaiddon, C. (2016). Structural tuning of organoruthenium compounds allows oxidative switch to control ER stress pathways and bypass multidrug resistance. Chemical Science, 7(7), 4117–4124. https://doi.org/10.1039/c6sc00268d
von Grabowiecki, Y., Abreu, P., Blanchard, O., Palamiuc, L., Benosman, S., Mériaux, S., … Gaiddon, C. (2016). Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63. ELife, 5, e10528. https://doi.org/10.7554/eLife.10528
Rico Bautista, H., Saavedra Díaz, R. O., Shen, L. Q., Orvain, C., Gaiddon, C., Le Lagadec, R., & Ryabov, A. D. (2016). Impact of cyclometalated ruthenium(II) complexes on lactate dehydrogenase activity and cytotoxicity in gastric and colon cancer cells. Journal of Inorganic Biochemistry, 163, 28–38. https://doi.org/10.1016/j.jinorgbio.2016.07.014
Jung, A. C., Ray, A.-M., Ramolu, L., Macabre, C., Simon, F., Noulet, F., … Martin, S. (2015). Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties. Oncotarget, 6(39), 41884–41901. https://doi.org/10.18632/oncotarget.6099
Hanns, E., Job, S., Coliat, P., Wasylyk, C., Ramolu, L., Pencreach, E., … Jung, A. C. (2015). Human Papillomavirus-related tumours of the oropharynx display a lower tumour hypoxia signature. Oral Oncology, 51(9), 848–856. https://doi.org/10.1016/j.oraloncology.2015.06.003
Chamard-Jovenin, C., Jung, A. C., Chesnel, A., Abecassis, J., Flament, S., Ledrappier, S., … Dumond, H. (2015). From ERα66 to ERα36: a generic method for validating a prognosis marker of breast tumor progression. BMC Systems Biology, 9, 28. https://doi.org/10.1186/s12918-015-0178-7
Tasan, S., Licona, C., Doulain, P.-E., Michelin, C., Gros, C. P., Le Gendre, P., … Bodio, E. (2015). Gold-phosphine-porphyrin as potential metal-based theranostics. Journal of Biological Inorganic Chemistry: JBIC: A Publication of the Society of Biological Inorganic Chemistry, 20(1), 143–154. https://doi.org/10.1007/s00775-014-1220-8
von Grabowiecki, Y., Licona, C., Palamiuc, L., Abreu, P., Vidimar, V., Coowar, D., … Gaiddon, C. (2015). Regulation of a Notch3-Hes1 pathway and protective effect by a tocopherol-omega alkanol chain derivative in muscle atrophy. The Journal of Pharmacology and Experimental Therapeutics, 352(1), 23–32. https://doi.org/10.1124/jpet.114.216879
Chow, M. J., Licona, C., Yuan Qiang Wong, D., Pastorin, G., Gaiddon, C., & Ang, W. H. (2014). Discovery and investigation of anticancer ruthenium-arene Schiff-base complexes via water-promoted combinatorial three-component assembly. Journal of Medicinal Chemistry, 57(14), 6043–6059. https://doi.org/10.1021/jm500455p
Klajner, M., Licona, C., Fetzer, L., Hebraud, P., Mellitzer, G., Pfeffer, M., … Gaiddon, C. (2014). Subcellular localization and transport kinetics of ruthenium organometallic anticancer compounds in living cells: a dose-dependent role for amino acid and iron transporters. Inorganic Chemistry, 53(10), 5150–5158. https://doi.org/10.1021/ic500250e
Robertson, E. D., Wasylyk, C., Ye, T., Jung, A. C., & Wasylyk, B. (2014). The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PloS One, 9(11), e113050. https://doi.org/10.1371/journal.pone.0113050
Wasylyk, B., Abecassis, J., & Jung, A. C. (2013). Identification of clinically relevant HPV-related HNSCC: in p16 should we trust? Oral Oncology, 49(10), e33-37. https://doi.org/10.1016/j.oraloncology.2013.07.014
Anthwal, N., Pelling, M., Claxton, S., Mellitzer, G., Collin, C., Kessaris, N., … Ang, S.-L. (2013). Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity. Disease Models & Mechanisms, 6(5), 1133–1145. https://doi.org/10.1242/dmm.011916
Ennen, M., Klotz, R., Touche, N., Pinel, S., Barbieux, C., Besancenot, V., … Becuwe, P. (2013). DDB2: a novel regulator of NF-κB and breast tumor invasion. Cancer Research, 73(16), 5040–5052. https://doi.org/10.1158/0008-5472.CAN-12-3655
Jung, A. C., Job, S., Ledrappier, S., Macabre, C., Abecassis, J., de Reyniès, A., & Wasylyk, B. (2013). A poor prognosis subtype of HNSCC is consistently observed across methylome, transcriptome, and miRNome analysis. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 19(15), 4174–4184. https://doi.org/10.1158/1078-0432.CCR-12-3690
Jung, A. C. (2013). Can liberating p53 from E6 free patients from HPV-related head and neck tumors? Cell Cycle (Georgetown, Tex.), 12(6), 868. https://doi.org/10.4161/cc.24101
Boff, B., Gaiddon, C., & Pfeffer, M. (2013). Cancer cell cytotoxicity of cyclometalated compounds obtained with osmium(II) complexes. Inorganic Chemistry, 52(5), 2705–2715. https://doi.org/10.1021/ic302779q
Jung, A. C., Guihard, S., Krugell, S., Ledrappier, S., Brochot, A., Dalstein, V., … Abecassis, J. (2013). CD8-alpha T-cell infiltration in human papillomavirus-related oropharyngeal carcinoma correlates with improved patient prognosis. International Journal of Cancer, 132(2), E26-36. https://doi.org/10.1002/ijc.27776
Vidimar, V., Meng, X., Klajner, M., Licona, C., Fetzer, L., Harlepp, S., … Gaiddon, C. (2012). Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity. Biochemical Pharmacology, 84(11), 1428–1436. https://doi.org/10.1016/j.bcp.2012.08.022
Ribeiro, N., Thuaud, F., Bernard, Y., Gaiddon, C., Cresteil, T., Hild, A., … Désaubry, L. (2012). Flavaglines as potent anticancer and cytoprotective agents. Journal of Medicinal Chemistry, 55(22), 10064–10073. https://doi.org/10.1021/jm301201z
Guihard, S., Ramolu, L., Macabre, C., Wasylyk, B., Noël, G., Abecassis, J., & Jung, A. C. (2012). The NEDD8 conjugation pathway regulates p53 transcriptional activity and head and neck cancer cell sensitivity to ionizing radiation. International Journal of Oncology, 41(4), 1531–1540. https://doi.org/10.3892/ijo.2012.1584
Guihard, S., Jung, A. C., & Noël, G. (2012). [High-risk human papilloma virus associated oropharynx squamous cell carcinomas: clinical, biological implications and therapeutical perspectives]. Cancer Radiotherapie: Journal De La Societe Francaise De Radiotherapie Oncologique, 16(1), 34–43. https://doi.org/10.1016/j.canrad.2011.11.001
Bergamo, A., Gaiddon, C., Schellens, J. H. M., Beijnen, J. H., & Sava, G. (2012). Approaching tumour therapy beyond platinum drugs: status of the art and perspectives of ruthenium drug candidates. Journal of Inorganic Biochemistry, 106(1), 90–99. https://doi.org/10.1016/j.jinorgbio.2011.09.030
Benosman, S., Meng, X., Von Grabowiecki, Y., Palamiuc, L., Hritcu, L., Gross, I., … Gaiddon, C. (2011). Complex regulation of p73 isoforms after alteration of amyloid precursor polypeptide (APP) function and DNA damage in neurons. The Journal of Biological Chemistry, 286(50), 43013–43025. https://doi.org/10.1074/jbc.M111.261271
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